Protein Details: Store-operated calcium entry-associated regulatory factor

Protein ID

ICDB_Pro_1396

Protein Name

Store-operated calcium entry-associated regulatory factor

Gene Name

SARAF; TMEM66; XTP3; HSPC035; NPD003; PSEC0019; UNQ1967/PRO4499

Organism

Homo sapiens (Human)

Length

339 amino acids

AlphaFoldDB

AF-Q96BY9-F1-model_v4.pdb

Function

Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling; promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels; and thus preventing the overload of the cell with excessive Ca(2+) ions.

Sequence

MAAACGPGAAGYCLLLGLHLFLLTAGPALGWNDPDRMLLRDVKALTLHYDRYTTSRRLDPIPQLKCVGGTAGCDSYTPKVIQCQNKGWDGYDVQWECKTDLDIAYKFGKTVVSCEGYESSEDQYVLRGSCGLEYNLDYTELGLQKLKESGKQHGFASFSDYYYKWSSADSCNMSGLITIVVLLGIAFVVYKLFLSDGQYSPPPYSEYPPFSHRYQRFTNSAGPPPPGFKSEFTGPQNTGHGATSGFGSAFTGQQGYENSGPGFWTGLGTGGILGYLFGSNRAATPFSDSWYYPSYPPSYPGTWNRAYSPLHGGSGSYSVCSNSDTKTRTASGYGGTRRR

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Acrofacial Dysostosis;Cincinnati Type and Anemia;Congenital Dyserythropoietic;Type Iv

Location

Highly expressed in macrophages

DOI ID

10.1016/j.cell.2012.01.055; 10.1101/gr.140200; 10.1101/gr.1293003; 10.1093/dnares/12.2.117; 10.1038/ng1285; 10.1038/nature04406; 10.1101/gr.2596504; 10.1110/ps.04682504; 10.1159/000495494

RefSeq

NP_001271168.1 [Q96BY9-2]; NP_057211.4 [Q96BY9-1]